PRP & Rotator Cuff

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In vivo clinical and radiological effects of platelet-rich plasma on interstitial supraspinatus lesion: Case series

Results

Tear volume diminution was statistically significant (P = .007), and a >50% tear volume diminution was observed in 15 patients. A statistically significant improvement of Constant score (P < .001), SANE score (P = .001), and VAS (P < .001) was observed. In 21 patients, Constant score improvement reached the minimal clinical important difference of 10.4 points

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PRP & Knee Osteoarthritis

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Abstract

Background

 

A randomized clinical trial was conducted on 89 patients with KOA. The patients were given either PRP (n = 45) or HA (n = 44) intra‐articular injections.

Results

While both PRP and HA injections resulted in the improvement of all outcome measures at 3 and 6 months follow up, they were significantly better in the PRP group than in the HA group.

Conclusion

Intra‐articular injection of PRP is an effective treatment that reduced pain and improved functional status in patients with KOA. The clinical outcomes of the intra‐articular injections of PRP are associated with improved synovial hypertrophy and vascularity scores, and less effusion.

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PRP & Frozen Shoulder

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Int J Clin Pharmacol Ther. 2018 Jun 22. doi: 10.5414/CP203262. [Epub ahead of print]

Lin J.

Abstract

PURPOSE:

Platelet-rich plasma (PRP) has been utilized in the treatment of chronic injuries. The current study aimed to evaluate the efficiency of PRP in the treatment of frozen shoulder compared to procaine.

PRP and procaine were effective in treating frozen shoulder. PRP was more effective and had a more prolonged efficiency than the procaine control. Nevertheless, the definite conclusion should come from further large-scale clinical trials.
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Platelet rich plasma for the management of hair loss: Better alone or in combination?

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Eduardo Anitua PhD, MD, DDS, Ander Pino MSc, Pedro Jaén PhD, MD, Mª Rogelia Navarro MD

First published: 14 June 2018 https://doi.org/10.1111/jocd.12683

Summary

Platelet‐rich plasma (PRP) and autologous protein‐based treatments have recently emerged as a potential therapeutic approach for hair loss‐related disorders including androgenetic alopecia and alopecia areata. The safety and efficacy of repeated intradermal injections of PRP has proved to promote hair growth in a number of randomized clinical trials. Biologically active proteins and cytokines released upon platelet activation have shown to induce folliculogenesis and activate the anagen growing phase of dormant bulbs. Interestingly, further studies have revealed that combining PRP with other hair loss‐related products may enhance the final performance of the treatment. These synergistic approaches include Food and Drug Administration (FDA) approved drugs such as finasteride or minoxidil, bioactive macromolecules and cell‐based therapies. Here, recent research involving alone or combined therapy with platelet‐rich plasma for the management of hair loss‐related disorders are outlined and future prospects are discussed.

PRP & Osteochondritis Dissecans

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Osteochondritis Dissecans
Does platelet rich plasma really help?

Deepak Kumar SharmaCorrespondence information about the author Deepak Kumar Sharma, Narendra Kumar, Hitesh lalEmail the author Hitesh lal, Binay Kumar Sahu, Sumon Singphow Saikia

Osteochondritis dissecans is a common disorder of knee and can be treated by various methods, depending on age of patient and stability of chondral fragment. In Osteochondritis dissecans ICRS type III lesion i.e. articular cartilage discontinuity but no dislocation, variable rate of union as well as high rate of non-union was observed in previous studies when treated with arthroscopic or open reduction and fixation. In previous study it has been also shown that platelet rich plasma help in fracture healing. In this study we are trying to extend the benefit of platelet rich plasma to Osteochondritis dissecans lesion. We took six patients with OCD, ICRS scale of OCD type III lesion. All Patients were operated Arthroscopiclly. Chondral flap of OCD lesion were fixed with stainless steel cannulated cancellous screw. To enhance union we used platelet rich plasma injections. .We access the union of chondral fragment to parent bone and knee function. Chondral fragment united to parent bone in all patients. To access knee function we used Tagner- Lysholm knee scoring system, in this study preoperatively score was 52.8 where as postoperatively it was 91.8. This study showed PRP is helpful in healing of chondral flap as all the chondral flap of osteochondral lesion united in this study.