Effects of platelet-rich plasma on pain and muscle strength in patients with knee osteoarthritis.

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RESULTS:

The PRP group showed a significant reduction in the WOMAC-pain and -total scores compared to normal saline group (p < 0.05). Although a significantly greater percentage of knee strength (extensor > flexor) was found in the PRP group during a longer follow-up period, PRP treatment resulted in insignificant differences in muscle strength compared to normal saline.

CONCLUSIONS:

PRP treatment significantly improves pain, stiffness, and disability in patients with knee OA compared to normal saline treatment. Additional strength training is recommended to enhance muscle strength recovery.

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Platelet-rich plasma injection may be effective for alopecia

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The researchers found that hair density was significantly improved at day 28 and at month six for PRP versus PS (P = 0.0156 and 0.0313, respectively) and PPP (P = 0.042 and 0.046, respectively). There was significant histological improvement between day 28 and month six for PRP versus PPP and PS for vessels (P = 0.0160 and 0.021, respectively), collagen (P = 0.0036 and 0.032, respectively), and epithelium (P = 0.0138 and 0.022, respectively). There was no local toxicity.

"Our study suggests that subcutaneous PRP injections using controlled concentration of platelets and leukocytes improve hair growth," the authors write.

See source.

PRP and Alopecia

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Efficacy of subcutaneous injection of platelet-rich plasma in alopecia: A clinical and histological pilot study on a rat model with a six-month long-term follow-up experience.

PURPOSE:

To assess the potential of platelet-rich plasma (PRP) subcutaneous injection of to treat alopecia and to evaluate local toxicity.

RESULTS:

Hair density was significantly improved at D28 and at M6 for PRPQ+ vs PSQ+ (respectively, P = .0156 and P = .0313), PPPQ+ (respectively, P = .042 and P = .046). Significant histological improvement was observed between D28 and M6, for PRPQ+ vs PPPQ+ and PSQ+ for vessels (respectively, P = .0160 and P = .021), collagen (respectively, P = .0036 and P = .032), and epithelium (respectively, P = .0138 and P = .022) with no local toxicity.

CONCLUSION:

Our study suggests that subcutaneous PRP injections using controlled concentration of platelets and leukocytes improve hair growth.

SOURCE https://www.ncbi.nlm.nih.gov/pubmed/29130636

Advances in Hair Restoration

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Abstract

Hair loss affects millions of people worldwide and can have devastating effects on an individual's psychological and emotional well-being. Hair restoration technologies have advanced with the use of robotics and manual and motorized follicular unit extraction to provide patients excellent clinical results. Adjuvant modalities such as platelet-rich plasma injections, lasers and stem cells can further enhance the survivability and appearance of hair transplants.

Dermatol Clin. 2018 Jan;36(1):57-62. doi: 10.1016/j.det.2017.09.008.

Peritendinous injection of platelet-rich plasma to treat tendinopathy: A retrospective review.

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In the present retrospective study assessing PRP injections in the treatment of chronic tendinopathy, a moderate improvement (>50%) in pain symptoms was observed in most of the patients. Our research found that results were most promising with patellar and lateral epicondylar tendinopathy in the short to medium term. Female patients, patients with upper extremity tendinopathy and older patients appeared to benefit more from PRP injection.

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Latimer undergoes Platelet-rich Plasma procedure on ailing knee

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Further, per Klis, Latimer had a Platelet-rich Plasma procedure over the team's bye week. PRP entails drawing and spinning blood, then re-injecting the plasma, platelets and red and white blood cells into damaged tissue.

The procedure is commonly used for NBA and MLB athletes, though Falcons defender Adrian Clayborn had it done last December. Former Colts and Broncos quarterback Peyton Manning also turned to PRP to enhance his once-career-threatening neck injury.

 

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Allure Magazine: Here's What You Need to Know About Platelet-Rich Plasma Treatment for Hair Loss

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The use of PRP is "a great treatment option for hair loss because it has a number of scientifically based articles showing its efficacy increasing hair count, hair thickness, and the growth phase of the hair cycle," says Neil Sadick, dermatologist in New York City and the director of the Sadick Research Group for understanding and treating hair loss. He adds the treatment has been gaining popularity around the world within the last few years.

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Combined platelet-rich plasma and lipofilling treatment provides great improvement in facial skin-induced lesion regeneration for scleroderma patients

Results

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Histopathological and phenotypical analysis of adipose tissue from SSc patients revealed a disorganization of its distinct architecture coupled with an altered cell composition. Although AD-MSCs derived from SSc patients showed high multipotency, they failed to sustain a terminally differentiated progeny. Furthermore, SVFs derived from SSc patients differed from healthy donors in their MSC-like traits coupled with an aberrant cytokine production profile. Finally, the administration of PRP in combination with autologous SVF improved buccal’s rhyme, skin elasticity and vascularization for all of the SSc patients enrolled in this study.

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Platelet-rich plasma for the therapeutic management of temporomandibular joint disorders: a systematic review

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Four of the studies found PRP injections to be superior in terms of improvements in mandibular range of motion and pain intensity up to 12 months after treatment, while the remaining two studies found similar results for the different treatments. There is slight evidence for the potential benefits of intra-articular injections of PRP in patients with TMJ-OA. However, a standardized protocol for PRP preparation and application needs to be established.

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Effect of platelet-rich plasma on patients after blepharoplasty surgery.

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RESULTS:

Patient-reported data indicate that compared to the basal group, the PRP group showed no significant differences regarding pain, itching, or color, but had better values for stiffness and thickness (months 1 and 2) as well as scar irregularity (month 1). Data reported by the clinical observer showed that in comparison with the basal group, the PRP group showed no differences in vascularization or pigmentation, but had lower (better) scores regarding thickness, relief, and pliability (at all assessment times). The total assessment values from patients and the observer were significantly better for the PRP than the basal group.

CONCLUSION:

Autologous PRP treatment enhanced some parameters associated with healing properties, suggesting a potential therapeutic value after blepharoplasty surgery.

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Magnetic resonance and ultrasound in achilles tendinopathy: Predictive role and response assessment to platelet-rich plasma and adipose-derived stromal vascular fraction injection.

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In conclusion, both PRP and adipose-derived SVF injections seem to allow for clinical benefit in patients with NIAT, associated to an early slight increase of tendon thickness and neovascularization. Only after PRP injection there was a significant improve of MR signal intensity, even though very slight, whereas US morphologic appearance did not significantly change after both injective treatments. None of investigated MR and US parameters seems to have a predictive role in NIAT treated by PRP and adipose-derived SVF.

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Platelet-rich plasma stimulates angiogenesis in mice which may promote hair growth

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Results

At 13 and 18 days after the last injection, the hair length of mice in PRP group (4.24 ± 0.60 and 8.29 ± 0.48 mm, respectively) was significantly longer compared with the control group (3.70 ± 0.52 and 7.21 ± 0.64 mm, p < 0.05). No significant difference in the hair length was found between the PPP group and the control (p > 0.05). In addition, the number of CD31-positive vessel in the PRP group (9.90 ± 0.60) was more than that in the control group (8.60 ± 2.34, p < 0.05).

Conclusion

Platelet-rich plasma might promote hair length growth and increase the number of hair follicles by inducing angiogenesis.

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A Split Head Study of Efficacy of Placebo versus Platelet-rich Plasma Injections in the Treatment of Androgenic Alopecia.

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Conclusion

Hence, we can conclude PRP is an effective alternative modality in the treatment of AGA without remarkable adverse effects and is accompanied by a high satisfaction rate among patients. However, a randomised, double-blind study with larger cohort of patients and objective evaluation methods is needed.

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