Does Platelet-Rich Plasma Lead to Earlier Return to Sport When Compared With Conservative Treatment in Acute Muscle Injuries?

CONCLUSIONS:

Evidence from the current literature, although limited, suggests that the use of PRP may result in an earlier return to sport among patients with acute grade I or II muscle strains without significantly increasing the risk of reinjury at 6 months of follow-up. However, no difference in time to return to sport was revealed when specifically evaluating those with a grade I or II hamstring muscle strain.

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Platelet-rich plasma exhibits beneficial effects for rheumatoid arthritis mice by suppressing inflammatory factors.

In conclusion, CIA mice treated with PRP exhibited beneficial effects, including decreased joint inflammation, cartilage destruction and bone damage, and increased repair of joint tissue. The results of the present study suggested that PRP may be an effective therapeutic agent for RA.

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Original article: Platelet-rich plasma with microneedling in androgenetic alopecia along with dermoscopic pre- and post-treatment evaluation.

METHOD:

Patients with mild to moderate AGA, aged 18-45 years with Hamilton-Norwood score 1-5 were included in both study and control group. Dermoscopy was performed using Dermlite II hybrid m; 3Gen dermoscope at 10× magnification in polarized mode, and photographs were taken. Those not responding or those not having any new hair growth to conventional therapy for at least 1 year were included. The study group were given autologous platelet-rich plasma injections with microneedling over a period of 3 months at 3 weekly interval. Baseline and post-treatment photographs were taken.

RESULT:

Hair growth started after the first session. The patients' satisfaction was more than 75% in 18 patients, on patients' subjective hair growth assessment scale. In post-PRP-treated patients of AGA, increase in the number of vellus and total hairs, increased hair shaft diameter, and reduction in yellow dots were appreciated after 3 sessions. Hair pull test was negative after treatment in 14 patients (70%).

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Regenerative Medicine Using Platelet Rich Plasma and Stem Cells in Atrophic Acne Scars: A Case Report

Results

After one session of therapy, fading of hyperpigmentation marks was noted and the patient’s face looked more supple (Figure 2). Healing of acne pustules and papules was also noted. Reduction in prominence of boxcar and rolling acne scars was observed following second session of therapy. A transition to Grade 1 (mild acne scars) was noticed after the third session of therapy the results of which have been maintained till date (Figure 3).

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Platelet-rich plasma shows efficacy in combination treatment for androgenetic alopecia

Platelet-rich plasma in combination with 5% minoxidil solution showed efficacy in hair regrowth for patients with androgenetic alopecia compared with the combination with oral finasteride, according to study results recently published in Dermatologic Surgery.

Researchers studied 25 patients with androgenetic alopecia (13 females; mean age, 39.9 years). Thirteen patients were treated with 1 mL 5% topical minoxidil solution twice daily and 12 patients treated with 1 mg per day of oral finasteride.

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Ultrasound-guided perineural injection with platelet-rich plasma improved the neurophysiological parameters of carpal tunnel syndrome: A case report.

Highlights

  • •If patients are refractory to conservative treatments, PRP may be an alternative.
  • •PRP injection may improve the neurophysiological parameters of CTS.
  • •Ultrasonography-guided injection frees entrapped structures more accurately.

Learn more: Journal of Clinical Neuroscience

Comparative Efficacy of Platelet Rich Plasma Injection, Corticosteroid Injection and Ultrasonic Therapy in the Treatment of Periarthritis Shoulder.

Introduction: Periarthritis (PA) shoulder characterised by pain and restricted range of motion has a plethora of treatment options with inconclusive evidence. Platelet Rich Plasma (PRP) is an emerging treatment option and its efficacy needs to be examined and compared with other routine interventions.

Results: PRP treatment resulted in statistically significant improvements over corticosteroid and ultrasonic therapy in active as well as passive range of motion of shoulder, VAS and QuickDASH at 12 weeks. At six weeks, PRP treatment resulted in statistically significant improvements over ultrasonic therapy in VAS and QuickDASH. No major adverse effects were observed.

Conclusion: This study demonstrates that single injection of PRP is effective and better than corticosteroid injection or ultrasonic therapy in treatment of PA shoulder.

Source: Journal of Clinical and Diagnostic Research

Delayed union of humeral shaft fractures: comparison of autograft with and without platelet-rich plasma treatment: a randomized, single blinded clinical trial.

INTRODUCTION:

Despite an adequate orthopedic treatment with functional bracing, some patients develop a delayed union in humeral shaft fractures. The objective of the present study was to determine the bone consolidation time among patients with delayed union of diaphyseal humeral fractures who were managed with locking compression plate (LCP) fixation combined with an iliac crest autograft using platelet-rich plasma (PRP) as a co-adjuvant.

RESULTS:

A total of 16 patients were included. Both groups had similar demographic characteristics. The patients treated with PRP had an earlier beginning of bone consolidation. Furthermore, these same patients exhibited bone consolidation at 19.9 weeks, on average, in contrast to 25.4 weeks in the control group.

CONCLUSIONS:

The use of PRP promotes earlier bone consolidation in patients with delayed union of the humeral shaft.

Source:  Archives of Orthopaedic and Trauma Surgery

Autologous Platelet-rich Plasma versus Corticosteroid in the Management of Elbow Epicondylitis: A Randomized Study.

RESULTS:

Six months after treatment with PRP, patient's with elbow epicondylitis had a significant improvement in their VAS (P < 0.05) and MAYO (P < 0.05) in contrast to steroid, whereas no statistical difference was found between the two groups at 1 and 2 months after intervention.

CONCLUSION:
Treatment of patients with epicondylitis with PRP reduces pain and significantly increases function, exceeding the effect of corticosteroid injection.

Source:  International Journal of Applied Basic Medical Research

Growth Factor Variation in Two Types of Autologous Platelet Biomaterials: PRP Versus PRF.

Abstract

Autologous platelet biomaterials represent a key source of cytokines and growth factors extensively used for clinical and surgical applications involving tissue regeneration; wound healing and tissue repair. In this communication we discuss the growth factors released by activated platelet rich plasma (PRP) and platelet rich fibrin (PRF) releasate. Our study highlights that significantly higher growth factors (TGF-ß1) are released by activated PRP as compared to releasate of PRF. The various growth factors released by both platelet products are significantly higher than the baseline concentration in the whole blood and have different bio-mechanism hence should be individualized as per the clinical indication.

Source https://www.ncbi.nlm.nih.gov/pubmed/28596670

PRP & Facial Rejuvenation Platelet-rich plasma injections show efficacy in facial skin biostimulation

The use of PRP rich in platelets and poor in leukocytes can provide objective improvements in skin biostimulation,” the researchers concluded. “Although a pilot study, our results may be useful for future studies on the specific cells and growth factors in PRP that contribute the facial rejuvenation.” – by Bruce Thiel

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A comparative study to evaluate the efficacy of platelet-rich plasma and triamcinolone to treat tennis elbow.

RESULTS:

Overall, 49 females and 31 males were included with thirty elbows in each group. Both the PRP and triamcinolone groups had better pain relief at 3 and 6 months as compared to normal saline group (P < 0.05), but at 6 months followup, the PRP group had statistically significant better pain relief than triamcinolone group. In the triamcinolone group, 13 patients had injection site hypopigmentation and 3 patients had subdermal atrophy.

CONCLUSION:

Over a short term period, PRP gives better pain relief than triamcinolone or normal saline in tennis elbow which needs to be validated over long term period by further studies.

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Wizards’ Kelly Oubre Jr. receives PRP treatment on right knee

Washington Wizards forward Kelly Oubre Jr. received platelet-rich plasma injections in his right knee Friday in Los Angeles, according to several people close to the situation.

Oubre, a second-year player who played through pain during the Wizards’ playoff run, is not expected to undergo further injections and will sit out the next few weeks to rest his knee. Although Oubre could resume basketball activities later this month but will not play with the Wizards’ Summer League team in July.

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Effect of platelet concentration on clinical improvement in treatment of early stage-knee osteoarthritis with platelet-rich plasma concentrations.

[Purpose] To compare two platelet-rich plasma kits with different platelet concentrations for treatment of knee osteoarthritis. [Subjects and Methods] Male and female patients with knee osteoarthritis who had confirmed diagnosis with X-ray and magnetic resonance imaging were included in this retrospective study. Eligible patients were divided into two groups: Group I, which received platelet-rich plasma kit I, and Group II, which received platelet-rich plasma kit II. Platelet concentrations of both kits were measured by manual counting. For each group, platelet-rich plasma kit was injected twice with a one-month interval between injections. The Western Ontario and McMaster Universities Osteoarthritis Index and the Visual Analog Scale were applied for clinical evaluation before the first injection and one, three and six months after the second injection. [Results] Kits I and II contained 1,000,000 and 3,000,000 platelets/µl respectively. In both groups, initial Western Ontario and McMaster Universities Osteoarthritis Index and Visual Analog Scale scores were significantly higher compared to the latter evaluations. However, no significant difference was observed between groups in terms of clinical evaluations.

[Conclusion] Similar clinical results were found in groups receiving different platelet concentrations, therefore, a concentration of 1,000,000 platelet/µl is considered sufficient for pain relief and functional recovery.

Source: Journal of Physical Therapy Science

Therapeutic effect of microneedling and autologous platelet-rich plasma in the treatment of atrophic scars: A randomized study.

Background

New treatments and techniques were being added over the last few years to treat atrophic scars with variable results and adverse effects.

Aim of the work

The aim of this study was to evaluate and compare the therapeutic efficacy and safety of microneedling, autologous platelet-rich plasma, and combination of both procedures in the treatment of atrophic scars.

Patients and methods

This study included 90 patients with atrophic scars and were classified randomly into three groups: I: 28 patients treated with microneedling, one session every 4 weeks; II: 34 patients treated with intradermal injection of platelet-rich plasma, one session every 2 weeks; and III: 28 patients treated with alternative sessions of each microneedling and platelet-rich plasma, 2 weeks between each session, for a maximum of six sessions.

Results

There was a statistically significant improvement in the appearance of atrophic scars, with reduction in the scores associated with the clinical evaluation scale for atrophic scarring in all groups, but the improvement was more obvious in group III.

Conclusions

Although a single treatment may give good results, combination between skin needling and platelet-rich plasma is more effective, safe with less number of sessions in all types of atrophic scars.

 Journal of Cosmetic Dermatology.