A randomized clinical trial was conducted on 89 patients with KOA. The patients were given either PRP (n = 45) or HA (n = 44) intra‐articular injections.
While both PRP and HA injections resulted in the improvement of all outcome measures at 3 and 6 months follow up, they were significantly better in the PRP group than in the HA group.
Intra‐articular injection of PRP is an effective treatment that reduced pain and improved functional status in patients with KOA. The clinical outcomes of the intra‐articular injections of PRP are associated with improved synovial hypertrophy and vascularity scores, and less effusion.